눈물층의 기질 금속단백분해효소 9 검사와 건성안의 증상 및 징후의 상관관계

The Correlation between MMP-9 Point-of-Care Assay and Clinical Symptoms and Signs of Dry Eye Disease

한수연⋅소하림⋅이승훈⋅백지원⋅나호⋅강남여⋅김은철

Su yeon Han, MD, Ha rim So, MD, Seung hoon Lee, MD, Ji won Baek, MD, PhD, Ho Ra, MD, PhD, Nam yeo Kang, MD, PhD, Eun chul Kim, MD, PhD

가톨릭대학교 의과대학 부천성모병원 안과학교실

Department of Ophthalmology, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon, Korea

Purpose: To evaluate the correlation between matrix metalloproteinase-9 (MMP-9) point-of-assay and clinical symptoms and signs of dry eye disease.

Methods: We performed a retrospective study for patients diagnosed with dry eye. MMP-9 (InflammaDry) was performed on 235 patients. Patients were assessed using Schirmer test, corneal staining score, tear film breakup time (TBUT) and the Ocular Surface Disease Index (OSDI). Results: The score of Schirmer test was lower significantly in MMP-9 positive group than in MMP-9 negative group (for each 4.21 ± 5.80 mm, 5.96 ± 8.14 mm; p = 0.035). TBUT was shorter significantly in MMP-9 positive group than in MMP-9 negative group (for each 5.46 ± 4.06 s, 8.27 ± 4.75 s; p = 0.0008). The ratio of positive corneal stain (for each 83%, 31%) and OSDI even or greater than 13 (for each 80%, 75%) was significantly higher in MMP-9 positive group than in MMP-9 negative group (p = 0.00001, p = 0.0044). The value of MMP-9 point-of-care assay showed showed the negative correlation with Schirmer test (Rs = 0.383, p < 0.001), and TBUT (Rs = 0.310, p < 0.05), and showed the positive correlation with corneal staining score (Rs = 0.527, p < 0.001), OSDI (Rs = 0.510, p < 0.001).

Conclusions: MMP-9 point-of-assay accords with clinical symptoms and signs of Dry eye disease, and may be helpful in diag nosing Dry eye disease.

Key Words: Biomarker, Dry eye disease, Matrix metalloproteinase

Ann Optom Contact Lens 2024