성형안과 질환과 눈물막 내 기질금속단백질분해효소 9와의 연관성 분석

Matrix Metalloproteinases 9 Testing Using Immunoassay Kit in Oculoplastic Outpatient Clinic Patients

최완규1ㆍ박정우2ㆍ한지상1

Wan kyu Choi, MD1, Jung woo Park, MD2, Jisang Han, MD1

성균관대학교 의과대학 강북삼성병원 안과학교실1, 대한민국 공군2

Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine1, Seoul, Korea Republic of Korea Air Force

Purpose: We assessed the association between the results of tear film-based matrix metalloproteinases 9 (MMP-9) immuno assay and the diagnosis of patients who visited an oculoplastic outpatient clinic.

Methods: We conducted a retrospective analysis of the MMP-9 immunoassay results in 1,703 eyes from 1,703 patients who pre sented with ocular discomfort at an oculoplastic outpatient clinic. The MMP-9 immunoassay results were analyzed in correlation with the final oculoplastic diagnosis of the patients.

Results: In total, 1,126 of 1,533 eyes demonstrated positive expression of MMP-9. No statistically significant differences were observed in MMP-9 expression based on sex (p = 0.107) and age (p = 0.510). Furthermore, 120 of 169 eyes with thyroid eye dis ease (71.0%, p < 0.001), 145 of 161 eyes with nasolacrimal duct obstruction (90.1%, p < 0.001), 282 of 375 eyes with nasolacri mal duct stenosis (75.2%, p < 0.001), 190 of 238 eyes with entropion (79.8%, p < 0.001), 19 of 23 eyes with ectropion (82.6%, p < 0.001), and 370 of 567 eyes with dry eye syndrome (65.3%, p < 0.001) exhibited positive MMP-9 expression. Conclusions: The MMP-9 immunoassay is a noninvasive, convenient, and rapid test that evaluates ocular surface inflammation. Most patients with oculoplastic diseases exhibit positive MMP-9 expression. These findings provide valuable information for guiding diagnostic and management decisions in patients with oculoplastic conditions.

Keywords: Ectropion, Entropion, MMP-9 immunoassay, Nasolacrimal duct obstruction, Thyroid eye disease

J Korean Ophthalmol Soc 2023