|제목||InflammaDry 논문 - Assessment of reliability and validity of the 5‑scale|
Assessment of reliability and validity of the 5‑scale grading system of the point‑of‑care immunoassay for tear matrix metalloproteinase‑9
We evaluated the reliability and validity of the 5-scale grading system to interpret the point-ofcare immunoassay for tear matrix metalloproteinase (MMP)-9. Six observers graded red bands of photographs of the readout window in MMP-9 immunoassay kit (InflammaDry) two times with 2-week interval based on the 5-scale grading system (i.e. grade 0–4). Interobserver and intraobserver reliability were evaluated using intraclass correlation coefficients. The interobserver agreements were analyzed according to the severity of tear MMP-9 expression. To validate the system, a concentration calibration curve was made using MMP-9 solutions with reference concentrations, then the distribution of MMP-9 concentrations was analyzed according to the 5-scale grading system.
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